ACE2 and infection: However, the infection promoted by SNX27 depletion is dramatically blocked by lysosomotropic agents (e.g., ammonium chloride and chloroquine) but not the early pathway inhibitor Camostat mesylate (Fig. 3C), suggesting more ACE2/virus complex reached lysosome/late endosome with the depletion of SNX27, and SNX27 diminishes infection by preventing viral lysosome/late endosome entry (Fig. 3E).