During the COVID-19 pandemic, the suspicion of a multisystemic inflammatory syndrome in children (MIS-C) is logical after a history of fever lasting more than 24 hours in individuals aged < 21 years, with evidence of inflammation (elevated levels of erythrocyte sedimentation rate, C-reactive protein, ferritin, and D-dimer); severe illness requiring hospitalization with multiple systems involving more than two systems, including echocardiogram findings; AKI; and dermatologic findings (rash, dry lips with crack), with fulfillment of partial criteria for atypical KD. Here, CRP is linked to acute kidney injury.