METTL3 is significantly increased in bladder cancer, which can interaction with DGCR8 promotes the maturation of pri-miR-221/222 family in an m6A dependent manner, reduces the expression of downstream gene PTEN through synergistic effect, and promotes the progression of bladder cancer and poor prognosis of patient [42] (Supplementary Table 3). This evidence concerns the gene DGCR8 and urinary bladder cancer.