In metastatic endometrial carcinoma, FTO can catalyze demethylation 3’-UTR region of HOXB13 mRNA, eliminate the recognition effect of YTHDF2 on the m6A methylation, reduce the attenuation effect of HOXB13 mRNA, and increasing the expression of HOXB13 can activate Wnt signaling pathway, thereby promoting tumor invasion and metastasis [48]. The gene discussed is FTO; the disease is neoplasm.