Studies have found that METTL3 plays a role of proto-oncogene in colorectal cancer, promotes the methylation level of Sox2 in a m6A dependent manner, prevents Sox2 degradation through the synergistic effect of IGF2BP2, and maintains the expression of Sox2, thus promoting the progression of colorectal cancer [99]. The gene discussed is METTL3; the disease is colorectal cancer.