In colorectal cancer, long non-coding RNA LINRIS blocks K139 ubiquitination of IGF2BP2, stabilizes the expression level of IGF2BP2 through autophagy lysosomal pathway, and promotes c-Myc mediated glycolysis through LINRIS-IGF2BP2-c-Myc axis, thereby promoting the progression of colorectal cancer [131]. This evidence concerns the gene IGF2BP2 and colorectal cancer.