In ovarian cancer, as a transcription factor, Sox2 directly binds to the promoter of ST6Gal-I to drive transcription and increases in N-glycosylated protein α2-6 linked sialic acid, promotes ST6Gal-I and α2-6-linked sialic acid expression, regulates glucose metabolism in cancer cells [97]. The gene discussed is ST6GAL1; the disease is ovarian carcinoma.