When co-cultured M2 macrophages with ovarian cancer cells, high expression of TLR4 activates NF-κB and up-regulates the expression of ALKBH5, decreases the m6A methylation level of NANOG thus promotes the expression of NANOG in ovarian cancer, thus promoting the occurrence and progression of ovarian cancer [55]. The gene discussed is ALKBH5; the disease is ovarian cancer.