METTL3 can directly interact with the 5’-UTR or 3’-UTR region of HK-2 and the 3’-UTR region of glucose transporter SLC2A1 (namely GLUT1), which is dependent on IGF2BP2 or IGF2BP3 to stabilize gene expression, and activate the downstream glycolysis pathway to regulate tumor cell progression [124]. The gene discussed is SLC2A1; the disease is neoplasm.