In the present study, the most promising biomarkers of neuroinflammation related to depression will be investigated including total CSF WCC, CSF/serum albumin ratio, CSF total protein, IgG index, CSF levels of IL-6 and IL-8, and any CNS-reactive autoantibody in CSF and/or blood. This evidence concerns the gene CXCL8 and depressive symptom measurement.