Furthermore, the gestational age and birth weight of P11 are relatively higher than that of other three patients with FZD4 mutations, and his clinical features are similar to that of Li et al. [16], who reported seven atypical ROP patients presenting significantly greater gestational age and birth weight compared with typical ROP patients, so the phenotype of P11 might be attributed to the type of atypical ROP. The gene discussed is FZD4; the disease is retinopathy of prematurity.