AIM2 and COVID-19: Beside the influence of CpG sites on the altered expression of ACE2R, an investigation by Castro de Moura et al. on peripheral blood samples isolated from COVID-19 patients indicated a significant correlation among the clinical severity of COVID-19 and 44 CpG sites, a good majority of which occur at the proximity of sequences coding for inflammasome components, including AIM2 and HLA-C [7].