Univariate Cox regression analysis showed that several clinicopathologic characteristics were associated with poor OS (Table 3), including advanced T stage (HR=1.668, P=0.003), N stage (HR=2.606, P<0.001), M stage (HR=2.111, P=0.007), poor pathologic stage (HR=2.975, P<0.001), worse treatment effect (HR=2.818, P<0.001), positive tumor status (HR=6.211, P<0.001) and low CHRDL1 (HR=0.598, P<0.001). This evidence concerns the gene CHRDL1 and neoplasm.