TBCE and hepatocellular carcinoma: Underlining the need to first characterize the healthy tissue before attempting to understand how disease perturbs the cells, we identify the DLL-NOTCH interaction to be an evolutionarily conserved cross-talk between homeostatic LSECs and KCs and therefore not unique to hepatocellular carcinoma or fibrosis, as proposed (Ramachandran et al., 2019; Sharma et al., 2020).