Furthermore, studies have demonstrated that blockade of the glycolytic enzyme PFKFB3 which leads to a decrease in RA FLS proliferation, migration, and invasive capacity is reversed in the presence of lactate, an effect mediated via PFKFB3-induced transcriptional activation of NF-κB and MAPKs [33]. The gene discussed is PFKFB3; the disease is rheumatoid arthritis.