AFP and hepatocellular carcinoma: In addition, in the analysis of 814 patients who did not develop HCC within 3 years and who were observed for more than 3 years, 16 patients developed HCC, and cirrhosis (HR: 5.775) and EOT-AFP ≥5.3 ng/mL (HR: 6.237) were associated with the development of HCC (Table 5).