Vascular smooth muscle cell (VSMC) loss in VSMC-specific progerin mice contributes to severe atherosclerosis, but recent studies in endothelium-specific progeria mice by us and others have also underpinned the importance of endothelial dysfunction in the development of age-related cardiovascular pathology in HGPS [24, 29, 30]. The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.