The relation between autophagy and ATF4 may not be limited to DLBCL cells, because our reanalysis of proteomic profiles generated in ATG5 knockout mouse embryonic fibroblasts (MEF) by Robin and colleagues (24) generally showed significant upregulation of proteins encoded by ATF4 target genes (Fig. 5F; Supplementary Fig. S5C–S5F). This evidence concerns the gene ATG5 and diffuse large B-cell lymphoma.