ATF4 and diffuse large B-cell lymphoma: Blocking autophagy by depleting ATG7 was also shown to reduce amino acid abundance in starved cells (27), and accordingly we observed that ATG5 depletion in DLBCL and 293T cells was accompanied by greater induction of ATF4 upon glutamine starvation (Fig. 6H and Supplementary Fig. S6C, respectively).