Finally, although ATF4 protein showed positive correlation with the relative abundance of phospho-EIF2A (p-EIF2A/EIF2A; Fig. 4D), the phospho-EIF2A levels only showed the trend of decrease in Sirt3−/− versus Sirt3WT lymphomas cells but was not statistically significant (Fig. 4E). Here, EIF2A is linked to lymphoma.