SIRT3 and diffuse large B-cell lymphoma: To explore pathways downstream of SIRT3 in an unbiased fashion, we performed RNA sequencing (RNA-seq) in three cell lines corresponding to OXPHOS (oxidative phosphorylation gene expression high: Karpas 422), GCB (GC B-cell like: OCI-LY1), and ABC (activated B-cell like: HBL1) DLBCL subtypes (15).