In addition, canonical pathway analysis showed that formyl-methionine-leucyl-phenylalanine (FMLP) signaling in neutrophils, protein kinase C (PKC) signaling in T lymphocytes and FCγ RIIB signaling in B lymphocytes were downregulated by PR8 infection but upregulated by PSMA2 KD, resulting in no impact during PSMA2 KD+PR8 infection (Fig. 4C). The gene discussed is FCGR2B; the disease is infection.