MARCHF8 and infection: As expected, infection by viruses pseudotyped with LCMV-GP or CHIKV-E3-E2-6K-E1, which are highly sensitive to MARCH8 (Fig. 1E and J), was still inhibited by the MARCH8 AxxL mutant (Fig. S4), as observed in VSV-G that is extremely MARCH8-sensitive (14, 15).