Undeniably, overproduction of GH and IGF-1 leads to complications of multiple systems, including mainly cardiomyopathy, ventilatory dysfunction, metabolic and endocrine complications, colonic polyps, and intestinal tumors (22, 67, 68), which may be related to the disturbance of the above-mentioned bacterial flora. This evidence concerns the gene IGF1 and cardiomyopathy.