We investigated the relationship between the expression levels of sTIM‐3, sCD137, sCD27, sLAG‐3, sIDO, Spd‐L2, sCD152, sCD80, sPD‐1, and the clinicopathological features (age, gender, smoking history, histological subtype, and TNM stage) of NSCLC patients. The gene discussed is LAG3; the disease is non-small cell lung carcinoma.