TNF and myotonic dystrophy type 1: Proinflammatory factors like IL6 and TNFA are necessary for the proliferation of muscle progenitor cells while suppressing further muscle differentiation (Otis et al., 2014), which is in line with these pathways being positively enriched in the first part of differentiation, and negatively enriched in the second part, both for DM1 and non-DM1 hESC lines.