Previous results in T47D mammary cancer cells have shown Hormone Control Regions, which include ERbs and PRbs acting in conjunction with FOXA1 and C/EBPa (Nacht et al., 2019) interact with promoters of hormone regulated genes in hormone-responsive TADs and organize the high level folding of the genome (Le Dily et al., 2019). The gene discussed is CEBPA; the disease is breast cancer.