All in all, it is now apparent that reduction in adiponectin levels may negatively affect its ability to reduce the amount of proinflammatory cytokines and ability to stimulate the content of anti-inflammatory ones (for instance, IL-10), and may also induce impaired expression of AipoR1, AdipoR2 and, above all, of T-cadherin [199]. The latter is a crucial molecule as any disturbances in its expression or functioning of T-cadherin or the binding of adiponectin correlate with endothelial dysfunction and pulmonary and cardiovascular pathologies [200]. The gene discussed is ADIPOQ; the disease is endothelial dysfunction.