All in all, ceramide lowering effects of adiponectin/T-cadherin is an important mechanism in protection against various organs and tissues damage, and against metabolic disturbances, while T-cadherin is a key binding partner for adiponectin [98]. In the heart T-cadherin was found to be crucial in mediating adiponectin effects against ischemia-reperfusion injury [99]. This evidence concerns the gene CDH13 and ischemia reperfusion injury.