Noteworthy, dissimilar to the above mentioned autoimmune conditions, adiponectin can act on keratinocytes and naïve T-cells and therefore has its rather an anti-inflammatory role in the pathogenesis of one more autoimmune disorder psoriasis by increasing the production of IL-10, while inhibiting the production and activity of IL-2, Il-6, IL-8, IL-17, IL-22, TNF-α and IFN-γ [162]. This evidence concerns the gene ADIPOQ and psoriasis.