ADIPOQ and infection: Nevertheless, in the publication of van Zelst C.M. et al. [186] in a relatively small number of patients not requiring intubation no difference in levels of serum adiponectin between COVID-19 negative and COVID-19 positive patients was found. On the contrary, in another study investigating a role of adipose tissue in COVID-19 onset it has been demonstrated that adiponectin levels were higher in patients with severe cases of the infection as compared to mild and moderate ones [187].