Patients with psoriasis have lower plasma adiponectin levels which thereby may lead to increased production of proinflammatory cytokines and lack of anti-inflammatory ones which eventually worsen the severity of their skin lesions. In keratinocytes the decrease in adiponectin levels has been shown to result in the reduced E2F1 gene activation through AMPK pathway promoting the proliferation of keratinocytes and inducing abnormal cell apoptosis thus interacting with the infiltration of the inflammatory response and leading to psoriasis [162]. The gene discussed is ADIPOQ; the disease is psoriasis.