This results were corroborated later in apoE-deficient knockout mice [224]. In adiponectin knockout mice insulin resistance, glucose intolerance, hyperlipidemia, hypertension and other metabolic syndrome-related traits were found as well as more abundant neointimal formation in response to injury unveiling the protective role of adiponectin [225][226]. In transgenic mice with the collagenous domain of adiponectin deletion elevation of circulating adiponectin levels leading to improved insulin sensitivity was reported [227]. The gene discussed is INS; the disease is Insulin resistance.