Moreover, taking into account the fact that the virus may reduce functional circulating ACE2 and one of the tissues where ACE2 is abundantly expressed is pancreatic β-cells, SARS-CoV-2 might target and disturb normal pancreatic function, alter glucose metabolism and induce de novo type 2 diabetes (T2DM ) [194]. The gene discussed is ACE2; the disease is type 2 diabetes mellitus.