It is also worth mentioning that influence of adiponectin in endocrine cancer cells may depend to some extent on paracrine interactions between tumor cells and neighboring adipocytes as these types of cells are often in close proximity to each other and one of such examples is the case of breast cancer, when adiponectin negatively modulates aromatase activity in adipocytes affecting estrogen production and reducing estrogen receptor alpha (ERα) stimulation in adjacent cancer cells [179]. This evidence concerns the gene ESR1 and malignant endocrine neoplasm.