Clinically‐related studies have shown that overexpression of IL‐13 and ILC2s in the urine are associated with bladder cancer.[21, 22] Recently, a highly polarized Th2 response to UTI has been reported to promote bladder epithelial regeneration.[66] Our data show that the type 2 immune response can be induced by UPEC infection. The gene discussed is IL13; the disease is bacterial urinary tract infection.