Patients with either ST-segment elevation MI (N = 3005) or non-ST-segment elevation MI (N = 3001) undergoing PCI and receiving a potent P2Y12 inhibitor (ticagrelor, prasugrel, or cangrelor) without the planned use of glycoprotein IIb/IIIa inhibitors were randomly assigned to receive bivalirudin or heparin during PCI, performed predominantly with the use of radial artery access. The gene discussed is P2RY12; the disease is myocardial infarction.