Diffusely growing gliomas in children and adolescents usually show genetic aberrations within the mitogen-activated protein kinase (MAPK) pathway and are characterized by the absence of isocitrate dehydrogenase (IDH) 1 and 2 hotspot and H3 histone, family 3A (H3F3A) mutations (Lazow et al. 2020). This evidence concerns the gene H3-3A and glioma.