Gal1 expression in the tumor vasculature serves the tumor in three important ways: (i) It provides the tumor with increased angiogenesis, (ii) it provides the tumor with metastatic potential, and (iii) it increases the barrier function of the tumor vasculature [40] for the formation of a leukocyte infiltrate, by providing an apoptotic signal to transmigrating leukocytes [10]. Here, LGALS1 is linked to neoplasm.