The numbers of S1 and S N M O peptide pool-specific IL2 and IL-2/IFN-γ -producing T cells were higher in severe/critical COVID-19 than mild/moderate patients between 6 and 15 months (p = 0.0044 and p = 0.0202 for S1 specific T cells, p = 0.0302, and p = 0.0427 for S N M O specific T cells), whereas no significant difference was observed in S1 and S N M O specific IFN-γ -producing T cells (p = 0.0610 and p = 0.1012, respectively) (Figures S5 and S6). Here, IFNG is linked to COVID-19.