GPER1 and neoplasm: Specific activation GPER1 by the drug G-1 (1(1-[4-(6-bromobenzo[1,3]dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]-ethanone) inhibited tumor growth and led to 60% necrosis of CRPC LNCaP-derived xenografts in castrated mice [17].