Further, they demonstrated that Smurf2 was able to modulate HIF-1α expression in clear cell renal cell carcinoma (ccRCC) cells lacking functional VHL, and their analysis of TCGA data demonstrated a positive correlation of SMURF2 overexpression and increased disease-free survival and overall survival in ccRCC. The gene discussed is SMURF2; the disease is clear cell renal carcinoma.