This study demonstrated that the MSCs from the hypoxic precondition culture were effective for therapy in male rats with testicular failure and infertility based on the increased of p63 expression as a quiescent cell marker as a crucial for progenitor of stem cell function and ETV5 expression as a transcriptional factor for regeneration of testicular tissue and improvement of the fertility of sperm. This evidence concerns the gene ETV5 and Infertility.