Moreover, compared to its non-lesion hemisphere, or to the post-stroke WT microglia (Fig. 2d-e), the post-stroke cKO microglia displayed a large number of downregulated genes that were mostly involved in inflammatory responses, such as the OX40 signaling pathway (Fig. 3a) involving in NF-kB activation45. This evidence concerns the gene NFKB1 and stroke disorder.