Alveolar rhabdomyosarcoma is characterized by the presence of chromosomal translocation t(1;13)(p36;q14) that results in PAX7–FOXO1 gene fusion; or translocation t(2;13)(q35;q14) that results in PAX3–FOXO1 gene fusion. This evidence concerns the gene FOXO1 and alveolar rhabdomyosarcoma.