To better understand the relevance of the tumor hypoxia in RMS, we interrogated the Schafer-Welle 56-MAS5.0-u133a data set in which 26 normal muscle samples were compared with 30 RMS patient samples (15 ARMS, 15 ERMS) and found that RMS patient samples significantly overexpress HIF-1α, a characteristic feature of hypoxia (Fig. 2A)40. The gene discussed is HIF1A; the disease is neoplasm.