Although we should investigate whether SMURF2Thr249 phosphorylation has a prognostic value for glioma patients, SMURF2 could exert tumor suppressor functions in glioma pathogenesis, in which SMURF2 activity is controlled by SMURF2Thr249 phosphorylation status rather than SMURF2 expression levels. The gene discussed is SMURF2; the disease is glioma.