SMURF2 and central nervous system cancer: Although we should investigate whether SMURF2Thr249 phosphorylation has a prognostic value for glioma patients, SMURF2 could exert tumor suppressor functions in glioma pathogenesis, in which SMURF2 activity is controlled by SMURF2Thr249 phosphorylation status rather than SMURF2 expression levels.