Here, we found a relative lower risk for needing assisted mechanical ventilation of 74% and better improvement in pre- and postprandial glucose levels in hospitalized patients with SARS-CoV-2 and hyperglycemia treated with linagliptin plus an insulin scheme than in those treated only with an insulin scheme; additionally, we found better clinical evolution in pulmonary parameters in patients in the LI group. The gene discussed is INS; the disease is Hyperglycemia.