In one study of 602 cognitively normal adults who underwent Aβ-amyloid PET imaging, and were followed longitudinally for six years, those who were APOE4 carriers but also KIBRA T allele carriers experienced significantly slower rates of cognitive decline and hippocampal atrophy than those who were non-KIBRA T allele carriers18. The gene discussed is APOE; the disease is Mental deterioration.