IDH2 and anaplastic astrocytoma: In multivariate Cox regression analysis, preoperative KPS only influenced PFS (HR 0.20, 95% CI 0.1–0.41, p < 0.0001), whereas histology (anaplastic astrocytoma: HR 5.3, 95% CI 1.23–22.8, p = 0.025; glioblastoma: HR 11.52, 95% CI 2.27–58.47, p = 0.0032), preoperative KPS ≥ 80 (HR 0.23,95% CI 0.09–0.62, p = 0.004), LN max ≥ 4.03 (HR 0.24, 95% CI 0.08–0.71, p = 0.01), and IDH status (HR 14.06, 95% CI 1.81–109.2, p = 0.011) were influential factors on OS (Table 3).