In particular, we tested the same model using CD8+ T cells from NY8.3 TCR transgenic mice, which are reactive against an epitope from the pancreatic islet cell antigen islet-specific glucose-6-phosphatase catalytic subunit related protein (IGRP) in the context of H-Kd MHC Class I, and are involved in the development of Type 1 diabetes in NOD mice. This evidence concerns the gene G6PC2 and type 1 diabetes mellitus.