These were: alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), apolipoprotein B (ApoB), calcium, glaucoma referral probability (GRP), LDL cholesterol (LDL), phosphate, sex hormone-binding globulin (SHBG), and triglycerides (TG), each of which has evidence of potentially non-linear relationships between covariates and the phenotype (Supplementary Figs. 4–13). Here, SHBG is linked to glaucoma.