BTNL2 and neoplasm: Depletion of Vγ1 γδ T cells also had a therapeutic effect on subcutaneous tumours, and following Vγ1 γδ T cell depletion the anti-tumour effect of BTNL2 blockade was comparable to that of controls, which indicates that the anti-tumour effect of BTNL2 blockade is dependent upon Vγ1 γδ T cells (Fig. 3e).