METTL6 and neoplasm: Furthermore, the importance of METTL2A/B- and METTL6-mediated m3C32 modification of tRNAsThr/Ser is emphasised by the findings that lack of METTL6 retards tumour cell growth and impairs pluripotency39, and that a pathogenic mutation in DALRD3, which impairs m3C32 installation in tRNAArg(CCU)/(UCU), is found in patients with developmental delay and early-onset epileptic encephalopathy40.