GATA4 and neoplasm: Interestingly, analysis of mice 8 weeks post-infection similarly revealed that somatic editing of Gata4 not only increased both the tumor burden and histopathological grade, but also total tumor numbers when compared to sgCtrl mice (Fig. 1e, f, g, Supplementary Fig. 1b), indicating that Gata4 loss may contribute to enhanced tumor initiation.