We find that the negative associations between GATA4 loss and immune infiltration are significant in 5 out of 8 tissue types when normalizing all other correlated and anticorrelated copy number events: breast invasive carcinoma, head and neck squamous cell carcinoma, lung squamous cell carcinoma, lung adenocarcinoma, and uterine corpus endometrial carcinoma (Fig. 3e). The gene discussed is GATA4; the disease is invasive breast carcinoma.