MYC and neoplasm: Second, since the top CNA covariate of loss of 8p is gain of 8q across tumor types (Supplementary Fig. 5b, c), possibly due to structural mechanisms like isochromosome formation, we specifically addressed the +8q covariate, particularly since 8q contains the prominent oncogene MYC. We analyzed tumors that lost 8p but did not gain 8q and found that 8p loss in the absence of 8q gain is still associated with lower levels of TIL-associated transcripts (Fig. 3d, Supplementary Fig. 7a, Supplementary Data 5).