Next, we determined in vivo efficacy of treatment with SNDX-5613 and/or venetoclax against a PDX model in NSG mice engrafted with AML cells harboring mtNPM1, DNMT3A, mtFLT3, IDH1, WT1, KMT2C, as well as other genes listed in Table S3. The gene discussed is DNMT3A; the disease is acute myeloid leukemia.