Next, we determined in vivo efficacy of treatment with SNDX-5613 and/or venetoclax against a PDX model in NSG mice engrafted with AML cells harboring mtNPM1, DNMT3A, mtFLT3, IDH1, WT1, KMT2C, as well as other genes listed in Table S3. This evidence concerns the gene KMT2C and acute myeloid leukemia.