These findings were associated with SNDX-50469-mediated downregulation of not only BCL2 and CDK6, as noted above, but also of MCL1 and to a lesser extent Bcl-xL in PD, CD34+ phenotypically characterized (by CyTOF analysis) AML stem/progenitor cells. This evidence concerns the gene BCL2 and acute myeloid leukemia.