KMT2A and acute myeloid leukemia: They demonstrate that co-treatment with SNDX-50469 and venetoclax or abemaciclib induced synergistic lethality in not only AML cell lines but also PD AML cells that harbor either MLL1-r or mtNPM1c along with FLT3-ITD and/or mtFLT3 (ITD or TKD).