Similar to the synergy observed in cultured cell lines, co-treatment with SNDX-50469 and venetoclax also displayed synergistic lethal activity against PD AML cells harboring MLL-AF9 (sample #7), MLL-AF9 plus FLT3-TKD (sample #4), MLL-ENL (sample #10), mtNPM1 (sample #6), mtNPM1 plus FLT3-TKD (samples #1, #5, and #8), and mtNPM1 plus FLT3-ITD and FLT3-TKD (sample #11) (Figs. 5A–F and S5A–C). Here, KMT2A is linked to acute myeloid leukemia.