TMPRSS2 and rectum adenocarcinoma: We found that TMPRSS2 was associated with various human diseases, such as cardiovascular disease, endocrine system diseases, immune system disease, respiratory or thoracic disease, infectious diseases (COVID-19 and severe acute respiratory syndrome) (Supplementary Figure 7A) and cancer or benign tumors (prostate carcinoma, gastric adenocarcinoma, colon adenocarcinoma, rectal adenocarcinoma, small cell lung carcinoma, etc) (Supplementary Figure 7B).