We found that TMPRSS2 was associated with various human diseases, such as cardiovascular disease, endocrine system diseases, immune system disease, respiratory or thoracic disease, infectious diseases (COVID-19 and severe acute respiratory syndrome) (Supplementary Figure 7A) and cancer or benign tumors (prostate carcinoma, gastric adenocarcinoma, colon adenocarcinoma, rectal adenocarcinoma, small cell lung carcinoma, etc) (Supplementary Figure 7B). Here, TMPRSS2 is linked to COVID-19.