The genes regulated by hepatic nuclear factors, Hnf1A (n = 112 target molecules in the dataset) and Hnf4A (n = 527) TRs, whose mutations are known to cause maturity-onset diabetes of the young (MODY) and insulin-independent diabetes mellitus [21, 22], were predicted to be inhibited by CUR. Here, HNF4A is linked to type 2 diabetes mellitus.