SLC30A8 and diabetes mellitus: Importantly, by demonstrating a mechanism through which ZnT8 inactivation may lead to resistance towards β-cell death in the longer term, while impairing glucose tolerance in the mouse in the short-term, our findings might provide an explanation for the protective effects towards diabetes of rare loss-of-function SLC30A8 alleles in man (Dwivedi et al. 2019).