A link was also seen between EpCAM and CD166 that represented co-expression of two markers (P = 0.02) and a significant direct correlation between EpCAM/CD166 phenotypes expression and tumor stage (P = 0.03), tumor differentiation (P = 0.05), neural, and lymph node invasion (P =0.01) in CRC tissues. The gene discussed is EPCAM; the disease is colorectal carcinoma.