Our findings showed the higher expression of EpCAM in 61.5% of CRC patients and the direct significant association of EpCAM expression with tumor size (P = 0.02), tumor stage (P = 0.007), tumor differentiation (P = 0.005), and vascular (P = 0.01), neural (P = 0.01), and lymph node (P = 0.001) invasion. The gene discussed is EPCAM; the disease is neoplasm.