In vivo and in vitro experiments found that TCAM1P inhibited the proliferation of cancer cells through interacted with insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1) and H1.2 linker histone, cluster member (HIST1H1C) and promoted DNA damage inducible transcript 3 (DDIT3) expression in HCC [15]. Here, H1-2 is linked to cancer.