The most frequent PPOs relative to the total of patients are summarized in Figure 1B, starting with vitamin D supplement in older people who are housebound or experiencing falls or with osteopenia (START criterion E5, 10.3%), followed by laxatives in patients receiving opioids regularly (H2, 6.8%), beta-blockers with stable systolic heart failure (A8, 5.3%) and ACE inhibitors with systolic heart failure and/or documented coronary artery disease (A6, 5.1%). This evidence concerns the gene ACE and systolic heart failure.