In addition, hyperphosphorylation of SRSF1 at multiple sites including SPSs at serine 199 and 201, via oncogenic activation of PI3k/Akt pathway, could result in differential alternative splicing of Casp9 which favors the prosurvival Casp9b isoform over the proapoptotic Casp9a isoform in non-small cell lung cancers (Shultz et al., 2010). This evidence concerns the gene AKT1 and non-small cell lung carcinoma.