We decided to focus on Phosphorylated Ser473 protein kinase (p-Akt) and Phosphorylated Thr202/Tyr204 extracellular signal-regulated protein kinases 1/2 (ERK1/2) as they are among the most commonly dysregulated proteins with oncogenic role in NSCLC [17, 18]. This evidence concerns the gene MAPK3 and non-small cell lung carcinoma.