FN1 and fibrosis: Quantitative analysis of tubulointerstitial fibrosis indicated that FA induced significant fibrosis compared with control from day 5 as shown by the bar graph in Figure 1H. Consistently, a marked induction of fibrotic markers collagen-1 (COL-1), collagen-3 (COL-3), and fibronectin (FN) was observed at day 7 (COL-1: 6.2-fold, COL-3: 5.8-fold, FN: 25.5-fold, P < 0.05, Supplemental Figure 1; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.143018DS1).