The mouse ENCODE transcriptome database (NCBI Gene; https://www.ncbi.nlm.nih.gov/) and Human Protein Atlas (27) reveal ZNF277/Zfp277 mRNA and protein expression in a wide variety of normal murine and human tissues, including the intestines, with strong nuclear staining in 22 of 24 human colon tumors. This evidence concerns the gene ZNF277 and colonic neoplasm.