More recently, thiophene derivative methyl 2-amino-6-(tert-butyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (TBTC) which was suggested to function as a preferential agonist of RXRα and is able to induce heterodimerisation of RXRα/LXRα and PPARγ/RXRα was demonstrated to reduce Aβ levels in cell culture as well as in AD animal model [153]. This evidence concerns the gene PPARG and Alzheimer disease.